Synthesis and characterisation of strontium carboxylates formed at room temperature and under hydrothermal conditions

A novel method was developed for the synthesis of highly pure strontium complexes in high yield. Syntheses proceeded along three pathways with optimum conditions being at T = 120-140°C, a base : acid ratio of 1.2 and 15 min reaction-time in an autoclave vessel. Large crystals were readily obtained within hours. The crystal structures of strontium R-glutamate hexahydrate (I) and strontium di(hydrogen S-glutamate) pentahydrate (II) were determined by X-ray powder diffraction methods at 295 K with Rietveld refinement (I: Space group P2₁2₁2₁, Z = 4, a = 7.3519(2), b = 8.7616(2), c = 20.2627(5) Å; II: Space group P2₁, Z = 2, a = 8.7243(1), b = 7.2635(1), c = 14.6840(2) Å, β = 100.5414(7)°). Synthesis at room temperature provided four additional new strontium compounds that may be applicable as constituents of pharmaceutical products for the treatment of bone conditions.