Synthesis, antimicrobial, and brine shrimps lethality assays of 3,3-diaryl-4-(1-methyl-1H-indol-3-yl)azetidin-2-ones

The paper describes the synthesis, characterization data, and biological activity (antibacterial, antifungal, and brine shrimps lethality) of new azetidin-2-ones. The compounds have been synthesized by the reaction of diarylketenes, generated in situ from thermal decomposition of the 2-diazo-1,2-diarylethanones, with N-(1-methyl-1H-indol-3-yl)methyleneamines. The compounds have been characterized by elemental analysis and spectral (IR, ¹H and ¹³C NMR, and MS) data. The paper also reports the results of antibacterial, antifungal, and brine shrimps lethality assays of these compounds. Some of the compounds exhibited significant biological activity.